Peroxisome Proliferator-Activated Receptor delta (PPARD) (N-Term) Peptide
PPARD
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN982042
Aperçu rapide pour Peroxisome Proliferator-Activated Receptor delta (PPARD) (N-Term) Peptide (ABIN982042)
Antigène
PPARD
(Peroxisome Proliferator-Activated Receptor delta (PPARD))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PPARD antibody (Catalog #: ARP38764_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))
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Sujet
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PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
Alias Symbols: FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, PPAR-beta, PPARB
Protein Interaction Partner: BCL6,HDAC7,NCOR2,BCL6,DUT,EP300,GADD45B,GADD45G,HDAC1,HDAC2,HDAC3,HDAC7,NCOR1,NCOR2,NR0B2,NRIP1,PEBP1,PPARD,PRDX6,PROX1,RANBP9,RXRA,RXRB,RXRG,SMAD9,SPEN,SRC,CEP350,GADD45G,Gadd45b,HDAC1,HDAC2,HDAC3,HDAC4,NCOR1,NCOR2,PPARD,SPEN
Protein Size: 441 -
Poids moléculaire
- 49 kDa
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ID gène
- 5467
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NCBI Accession
- NM_001039694, NP_001034783
Antigène
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